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The Src kinase Lyn is required for CCR5 signaling in response to MIP-1β and R5 HIV-1 gp120 in human macrophages

CCR5 is a receptor for several β chemokines and the entry coreceptor used by macrophage-tropic (R5) strains of HIV-1. In addition to supporting viral entry, CCR5 ligation by the HIV-1 envelope glycoprotein 120 (gp120) can activate intracellular signals in macrophages and trigger inflammatory mediato...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tomkowicz, Brian, Lee, Chuhee, Ravyn, Vipa, Cheung, Ricky, Ptasznik, Andrzej, Collman, Ronald G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society of Hematology 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895866/
https://ncbi.nlm.nih.gov/pubmed/16621960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-12-012815
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