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Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34(+) marrow cells

We studied the effects of Lyn ablation on CXCR4 receptor-mediated migration and adhesion of hematopoietic precursors. Down-regulation of Lyn expression with siRNA greatly reduced CXCR4-dependent hematopoietic cell movement, and increased cell adherence to stroma. This increase was associated with th...

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Detalhes bibliográficos
Main Authors: Nakata, Yuji, Tomkowicz, Brian, Gewirtz, Alan M., Ptasznik, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895784/
https://ncbi.nlm.nih.gov/pubmed/16467205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3343
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