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Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34(+) marrow cells
We studied the effects of Lyn ablation on CXCR4 receptor-mediated migration and adhesion of hematopoietic precursors. Down-regulation of Lyn expression with siRNA greatly reduced CXCR4-dependent hematopoietic cell movement, and increased cell adherence to stroma. This increase was associated with th...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society of Hematology
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895784/ https://ncbi.nlm.nih.gov/pubmed/16467205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3343 |
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