Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R)

Substance P (SP) is a potent modulator of monocyte/macrophage function. The SP-preferring receptor neurokinin-1 receptor (NK1R) has two forms: a full-length NK1R (NK1R-F) isoform and a truncated NK1R (NK1R-T) isoform, which lacks the terminal cytoplasmic 96-aa residues. The distribution of these rec...

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Detalhes bibliográficos
Main Authors: Chernova, Irene, Lai, Jian-Ping, Li, Haiying, Schwartz, Lynnae, Tuluc, Florin, Korchak, Helen M., Douglas, Steven D., Kilpatrick, Laurie E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Society for Leukocyte Biology 2009
Assuntos:
Receptors, Signal Transduction, and Genes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626768/
https://ncbi.nlm.nih.gov/pubmed/18835883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0408260
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