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BCR-ABL1 alters SDF-1α–mediated adhesive responses through the β(2) integrin LFA-1 in leukemia cells
Stromal-derived factor-1 (SDF-1) and its receptor, CXCR4, are essential for normal hematopoietic progenitor cell movement and adherence within the bone marrow microenvironment. In leukemia, the BCR-ABL1 oncoprotein inhibits SDF-1–dependent cell trafficking within the bone marrow through a mechanism...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2384141/ https://ncbi.nlm.nih.gov/pubmed/18339898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-117705 |
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