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N-n-alkylnicotinium analogs, a novel class of antagonists at α4β2* Nicotinic acetylcholine receptors: Inhibition of S(-)-nicotine-evoked 86Rb+Efflux from rat thalamic synaptosomes

PyridineN-n-alkylation of S(-)-nicotine (NIC) affordsN-n-alkylnicotinium analogs, previously shown to competitively inhibit [(3)H]NIC binding and interact with α4β2* nicotinic receptors (nAChRs). The present study determined the ability of the analogs to inhibit NIC-evoked(86)Rb(+) efflux from rat t...

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Detaylı Bibliyografya
Asıl Yazarlar: Wilkins, Lincoln H., Miller, Dennis K., Ayers, Joshua T., Crooks, Peter A., Dwoskin, Linda P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer-Verlag 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750962/
https://ncbi.nlm.nih.gov/pubmed/16594645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/aapsj070490
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