Wird geladen...
Gene Targeting Demonstrates That α4 Nicotinic Acetylcholine Receptor Subunits Contribute to Expression of Diverse [(3)H]Epibatidine Binding Sites and Components of Biphasic (86)Rb(+) Efflux With High and Low Sensitivity to Stimulation by Acetylcholine
[(3)H]Epibatidine binds to nAChR subtypes in mouse brain with higher (K(D)≈0.02 nM) and lower affinity (KD≈7 nM), which can be further subdivided through inhibition by selected agonists and antagonists. These subsets are differentially affected by targeted deletion of α7, β2 or β4 subunits. Most, bu...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577786/ https://ncbi.nlm.nih.gov/pubmed/17631923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2007.05.021 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|