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Gene Targeting Demonstrates That α4 Nicotinic Acetylcholine Receptor Subunits Contribute to Expression of Diverse [(3)H]Epibatidine Binding Sites and Components of Biphasic (86)Rb(+) Efflux With High and Low Sensitivity to Stimulation by Acetylcholine
[(3)H]Epibatidine binds to nAChR subtypes in mouse brain with higher (K(D)≈0.02 nM) and lower affinity (KD≈7 nM), which can be further subdivided through inhibition by selected agonists and antagonists. These subsets are differentially affected by targeted deletion of α7, β2 or β4 subunits. Most, bu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577786/ https://ncbi.nlm.nih.gov/pubmed/17631923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2007.05.021 |
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