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Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis

The actions of RhoA in cytoskeletal regulation have been extensively studied. RhoA also contributes to proliferation and oncogenic transformation by less well-characterized means. Elevated RhoA signalling has been associated with human cancer; through increased RhoA expression, mutation or elevated...

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Bibliographic Details
Main Authors: Morin, Pierre, Flors, Cristina, Olson, Michael F.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750871/
https://ncbi.nlm.nih.gov/pubmed/19515453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejcb.2009.04.005
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