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Deregulation of HEF1 Impairs M-Phase Progression by Disrupting the RhoA Activation Cycle

The focal adhesion-associated signaling protein HEF1 undergoes a striking relocalization to the spindle at mitosis, but a function for HEF1 in mitotic signaling has not been demonstrated. We here report that overexpression of HEF1 leads to failure of cells to progress through cytokinesis, whereas de...

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Bibliografiske detaljer
Main Authors: Dadke, Disha, Jarnik, Michael, Pugacheva, Elena N., Singh, Mahendra K., Golemis, Erica A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382310/
https://ncbi.nlm.nih.gov/pubmed/16394104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-03-0237
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