A Conserved RhoGAP Limits M-phase Contractility and Coordinates with Microtubule Asters to Restrict Active RhoA to the Cell Equator During Cytokinesis

During animal cell cytokinesis, the spindle directs contractile ring assembly by activating RhoA in a narrow equatorial zone. Rapid GTPase activating protein (GAP)-mediated inactivation (RhoA flux) is proposed to limit RhoA zone dimensions. Testing the significance of RhoA flux has been hampered by...

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Gepubliceerd in:Dev Cell
Hoofdauteurs: Zanin, Esther, Desai, Arshad, Poser, Ina, Toyoda, Yusuke, Andree, Cordula, Moebius, Claudia, Bickle, Marc, Conradt, Barbara, Piekny, Alisa, Oegema, Karen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239416/
https://ncbi.nlm.nih.gov/pubmed/24012485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.08.005
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