Islet β-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli

OBJECTIVE: Bcl-xL is an antiapoptotic member of the Bcl-2 family of proteins and a potent regulator of cell death. We investigated the importance of Bcl-xL for β-cells by deleting the Bcl-x gene specifically in β-cells and analyzing their survival in vivo and in culture. RESEARCH DESIGN AND METHODS:...

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Detalhes bibliográficos
Main Authors: Carrington, Emma M., McKenzie, Mark D., Jansen, Elisa, Myers, Michelle, Fynch, Stacey, Kos, Cameron, Strasser, Andreas, Kay, Thomas W., Scott, Clare L., Allison, Janette
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750233/
https://ncbi.nlm.nih.gov/pubmed/19581414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1602
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