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Kinase-dependent and -independent functions of the p110β phosphoinositide-3-kinase in cell growth, metabolic regulation and oncogenic transformation

Upon activation by receptors, the ubiquitously expressed Class IA isoforms (p110α and p110β) of phosphoinositide-3-kinase (PI3K) generate lipid second messengers, which initiate multiple signal transduction cascades1–5. Recent studies have demonstrated specific roles for p110α in growth factor and i...

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Detalhes bibliográficos
Main Authors: Jia, Shidong, Liu, Zhenning, Zhang, Sen, Liu, Pixu, Zhang, Lei, Lee, Sang Hyun, Zhang, Jing, Signoretti, Sabina, Loda, Massimo, Roberts, Thomas M., Zhao, Jean J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750091/
https://ncbi.nlm.nih.gov/pubmed/18594509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07091
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