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Kinase-dependent and -independent functions of the p110β phosphoinositide-3-kinase in cell growth, metabolic regulation and oncogenic transformation
Upon activation by receptors, the ubiquitously expressed Class IA isoforms (p110α and p110β) of phosphoinositide-3-kinase (PI3K) generate lipid second messengers, which initiate multiple signal transduction cascades1–5. Recent studies have demonstrated specific roles for p110α in growth factor and i...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2750091/ https://ncbi.nlm.nih.gov/pubmed/18594509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07091 |
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