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A constitutively activated form of the p110β isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice
Recent work has shown that ablation of p110β, but not p110α, markedly impairs tumorigenesis driven by loss of phosphatase and tensin homolog (PTEN) in the mouse prostate. Other laboratories have reported complementary data in human prostate tumor lines, suggesting that p110β activation is necessary...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890726/ https://ncbi.nlm.nih.gov/pubmed/20534477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005642107 |
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