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Probing Akt-inhibitor interaction by chemical cross-linking and mass spectrometry

The serine/threonine kinase Akt is a critical enzyme that regulates cell survival. As high Akt activity has been shown to contribute to the pathogenesis of various human malignancies, inhibition of Akt activation is a promising therapeutic strategy for cancers. We have previously demonstrated that c...

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Detalhes bibliográficos
Main Authors: Huang, Bill X., Kim, Hee-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750033/
https://ncbi.nlm.nih.gov/pubmed/19446470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jasms.2009.04.004
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