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Probing Akt-inhibitor interaction by chemical cross-linking and mass spectrometry
The serine/threonine kinase Akt is a critical enzyme that regulates cell survival. As high Akt activity has been shown to contribute to the pathogenesis of various human malignancies, inhibition of Akt activation is a promising therapeutic strategy for cancers. We have previously demonstrated that c...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2750033/ https://ncbi.nlm.nih.gov/pubmed/19446470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jasms.2009.04.004 |
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