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Regulatory Mechanism of Matrix Metalloprotease-2 Enzymatic Activity by Factor Xa and Thrombin

Matrix metalloprotease (MMP)-2 plays a key role in many biological and pathological processes related to cell migration, invasion, and mitogenesis. MMP-2 is synthesized as a zymogen that is activated through either a conformational change or proteolysis of the propeptide. Several activating enzymes...

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Detalhes bibliográficos
Main Authors: Koo, Bon-Hun, Park, Michael Y., Jeon, Ok-Hee, Kim, Doo-Sik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749111/
https://ncbi.nlm.nih.gov/pubmed/19581306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036848
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