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Thrombin-dependent MMP-2 Activity Is Regulated by Heparan Sulfate
Like most metalloproteases, matrix metalloprotease 2 (MMP-2) is synthesized as a zymogen. MMP-2 propeptide plays a role in inhibition of catalytic activity through a cysteine-zinc ion pairing, disruption of which results in full enzyme activation. A variety of proteases have been shown to be involve...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009852/ https://ncbi.nlm.nih.gov/pubmed/21041295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.171595 |
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