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The Thrombin-sensitive Region of Protein S Mediates Phospholipid-dependent Interaction with Factor Xa

To test the hypothesis that factor Xa (fXa) interacts with protein S, fXa was labeled active-site specifically with a dansyl (D) dye via a Glu-Gly-Arg (EGR) tether to yield DEGR-fXa(i). When protein S was added to phosphatidylcholine/phosphatidylserine (PC/PS, 4:1) vesicle-bound DEGR-fXa(i), the ani...

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Detalhes bibliográficos
Main Authors: Yegneswaran, Subramanian, Hackeng, Tilman M., Dawson, Philip E., Griffin, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586267/
https://ncbi.nlm.nih.gov/pubmed/18784085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806527200
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