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Crystal Structure and Acyl Chain Selectivity of Escherichia coli LpxD, the N-Acyltransferase of Lipid A Biosynthesis
LpxD catalyzes the third step of lipid A biosynthesis, the R-3-hydroxyacyl-ACP-dependent N-acylation of UDP-3-O-(acyl)- α-D-glucosamine, and is a target for new antibiotic development. Here we report the 2.6 Å crystal structure of the Escherichia coli LpxD homotrimer (EcLpxD). As is the case in Chla...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748855/ https://ncbi.nlm.nih.gov/pubmed/19655786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901025v |
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