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Purification and Mutagenesis of LpxL, the Lauroyltransferase of Escherichia coli Lipid A Biosynthesis
Escherichia coli lipid A is a hexa-acylated disaccharide of glucosamine with secondary laurate and myristate chains on the distal unit. Hexa-acylated lipid A is a potent agonist of human Toll-like receptor 4, whereas its tetra- and penta-acylated precursors are antagonists. The inner membrane enzyme...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664092/ https://ncbi.nlm.nih.gov/pubmed/18656959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800873n |
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