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Probing S4 and S5 Segment Proximity in Mammalian Hyperpolarization Activated HCN Channels by Disulfide Bridging and Cd(2+) Coordination
We explored the structural basis of voltage sensing in HCN1 hyperpolarization-activated channels by examining the relative orientation of the voltage-sensor and pore domains. The opening of channels engineered to contain single cysteine residues at the extracellular ends of the voltage-sensing S4 (V...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748781/ https://ncbi.nlm.nih.gov/pubmed/19034494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-008-0613-3 |
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