Probing S4 and S5 Segment Proximity in Mammalian Hyperpolarization Activated HCN Channels by Disulfide Bridging and Cd(2+) Coordination

We explored the structural basis of voltage sensing in HCN1 hyperpolarization-activated channels by examining the relative orientation of the voltage-sensor and pore domains. The opening of channels engineered to contain single cysteine residues at the extracellular ends of the voltage-sensing S4 (V...

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Hlavní autoři: Bell, Damian C., Turbendian, Harma K., Valley, Matthew T., Zhou, Lei, Riley, John H., Siegelbaum, Steven A., Tibbs, Gareth R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748781/
https://ncbi.nlm.nih.gov/pubmed/19034494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-008-0613-3
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