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VOLTAGE-DEPENDENT OPENING OF HCN CHANNELS: FACILITATION OR INHIBITION BY THE PHYTOESTROGEN, GENISTEIN, IS DETERMINED BY THE ACTIVATION STATUS OF THE CYCLIC NUCLEOTIDE GATING RING

Investigation of the mechanistic bases and physiological importance of cAMP regulation of HCN channels has exploited an arginine to glutamate mutation in the nucleotide-binding fold, an approach critically dependent on the mutation selectively lowering the channel’s nucleotide affinity. In apparent...

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Detalhes bibliográficos
Main Authors: Rozario, Anjali. O., Turbendian, Harma K., Fogle, Keri J., Olivier, Nelson B., Tibbs, Gareth R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775436/
https://ncbi.nlm.nih.gov/pubmed/19524546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2009.06.003
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