Distinct Nrf1/2-independent mechanisms mediate As3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes

Trivalent arsenite (As3+) is a known human carcinogen that is also capable of inducing apoptotic cell death. Increased production of reactive oxygen species is thought to contribute to both the carcinogenic and cytotoxic effects of As3+. Glutathione (GSH) constitutes a vital cellular defense mechani...

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Main Authors: Thompson, James A., White, Collin C., Cox, David P., Chan, Jefferson Y., Kavanagh, Terrance J., Fausto, Nelson, Franklin, Christopher C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748780/
https://ncbi.nlm.nih.gov/pubmed/19328227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.03.016
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