Nrf1 and Nrf2 Regulate Rat Glutamate-Cysteine Ligase Catalytic Subunit Transcription Indirectly via NF-κB and AP-1

Glutamate-cysteine ligase catalytic subunit (GCLC) is regulated transcriptionally by Nrf1 and Nrf2. tert-Butylhydroquinone (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (ARE). Interestingly, TBH also induces rat GCLC, but the rat GCLC promoter lack...

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Detalhes bibliográficos
Main Authors: Yang, Heping, Magilnick, Nathaniel, Lee, Candy, Kalmaz, Denise, Ou, Xiaopeng, Chan, Jefferson Y., Lu, Shelly C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168815/
https://ncbi.nlm.nih.gov/pubmed/15988009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.14.5933-5946.2005
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