Cloning and characterization of the 5'-flanking region of the rat glutamate-cysteine ligase catalytic subunit.

Glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione synthesis, is made up of two subunits, a catalytic (heavy) subunit (GCLC) and a modifier (light) subunit (GCLM), which are differentially regulated. Increased hepatic GCLC expression occurs during rapid growth, oxidative stress...

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Bibliographic Details
Main Authors: Yang, H, Wang, J, Huang, Z Z, Ou, X, Lu, S C
Format: Artigo
Language:Inglês
Published: 2001
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221971/
https://ncbi.nlm.nih.gov/pubmed/11439094
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