Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells...

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Detalhes bibliográficos
Main Authors: Palavalli, Lavanya H, Prickett, Todd D, Wunderlich, John R, Wei, Xiaomu, Burrell, Allison S, Porter-Gill, Patricia, Davis, Sean, Wang, Chenwei, Cronin, Julia C, Agrawal, Neena S, Lin, Jimmy C, Westbroek, Wendy, Hoogstraten-Miller, Shelley, Molinolo, Alfredo A, Fetsch, Patricia, Filie, Armando C, O’Connell, Michael P, Banister, Carolyn E, Howard, Jason D, Buckhaults, Phillip, Weeraratna, Ashani T, Brody, Lawrence C, Rosenberg, Steven A, Samuels, Yardena
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748394/
https://ncbi.nlm.nih.gov/pubmed/19330028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.340
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