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Analysis of the Disintegrin-metalloproteinases Family Reveals ADAM29 and ADAM7 Are Often Mutated in Melanoma
We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs)genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, A...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3103704/ https://ncbi.nlm.nih.gov/pubmed/21618342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21477 |
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