Analysis of the Disintegrin-metalloproteinases Family Reveals ADAM29 and ADAM7 Are Often Mutated in Melanoma

We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs)genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, A...

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Autors principals: Wei, Xiaomu, Moncada-Pazos, Angela, Cal, Santiago, Soria-Valles, Clara, Gartner, Jared, Rudloff, Udo, Lin, Jimmy C., Rosenberg, Steven A., López-Otín, Carlos, Samuels, Yardena
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103704/
https://ncbi.nlm.nih.gov/pubmed/21618342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21477
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