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Small Molecule Targets Env for Endoplasmic Reticulum-Associated Protein Degradation and Inhibits Human Immunodeficiency Virus Type 1 Propagation

Human immunodeficiency virus type 1 (HIV-1) is dependent on its envelope glycoprotein (Env) to bind, fuse, and subsequently infect a cell. We show here that treatment of HIV-1-infected cells with glycyl-prolyl-glycine amide (GPG-NH(2)), dramatically reduced the infectivity of the released viral part...

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Bibliografske podrobnosti
Main Authors: Jejcic, Alenka, Daniels, Robert, Goobar-Larsson, Laura, Hebert, Daniel N., Vahlne, Anders
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748041/
https://ncbi.nlm.nih.gov/pubmed/19640982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01700-08
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