Small Molecule Targets Env for Endoplasmic Reticulum-Associated Protein Degradation and Inhibits Human Immunodeficiency Virus Type 1 Propagation

Eitemau Tebyg

• GPG-NH(2 )acts via the metabolite αHGA to target HIV-1 Env to the ER-associated protein degradation pathway
  gan: Jejcic, Alenka, et al.
  Cyhoeddwyd: (2010)
• HIV-1 Vpr increases Env expression by preventing Env from endoplasmic reticulum-associated protein degradation (ERAD)
  gan: Zhang, Xianfeng, et al.
  Cyhoeddwyd: (2016)
• The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome
  gan: Manning, John T., et al.
  Cyhoeddwyd: (2020)
• Glycine-Amide Is an Active Metabolite of the Antiretroviral Tripeptide Glycyl-Prolyl-Glycine-Amide
  gan: Andersson, Elin, et al.
  Cyhoeddwyd: (2005)
• Reduction of HIV-1 Infectivity through Endoplasmic Reticulum-Associated Degradation-Mediated Env Depletion
  gan: Casini, Antonio, et al.
  Cyhoeddwyd: (2014)