GPG-NH(2 )acts via the metabolite αHGA to target HIV-1 Env to the ER-associated protein degradation pathway

BACKGROUND: The synthetic peptide glycyl-prolyl-glycine amide (GPG-NH(2)) was previously shown to abolish the ability of HIV-1 particles to fuse with the target cells, by reducing the content of the viral envelope glycoprotein (Env) in progeny HIV-1 particles. The loss of Env was found to result fro...

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Hlavní autoři: Jejcic, Alenka, Höglund, Stefan, Vahlne, Anders
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846875/
https://ncbi.nlm.nih.gov/pubmed/20230608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-20
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