Dominant CD8(+) T-Lymphocyte Responses Suppress Expansion of Vaccine-Elicited Subdominant T Lymphocytes in Rhesus Monkeys Challenged with Pathogenic Simian-Human Immunodeficiency Virus

Emerging data suggest that a cytotoxic T-lymphocyte response against a diversity of epitopes confers greater protection against a human immunodeficiency virus/simian immunodeficiency virus infection than does a more focused response. To facilitate the creation of vaccine strategies that will generat...

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Detalhes bibliográficos
Main Authors: Manuel, Edwin R., Yeh, Wendy W., Seaman, Michael S., Furr, Kathryn, Lifton, Michelle A., Hulot, Sandrine L., Autissier, Patrick, Letvin, Norman L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748023/
https://ncbi.nlm.nih.gov/pubmed/19641002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01015-09
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