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Crystal Structure Of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain: Insights Into Redox Regulation,
The lymphoid tyrosine phosphatase LYP, encoded by the PTPN22 gene, recently emerged as an important risk factor and drug target for human autoimmunity. Here we solved the structure of the catalytic domain of LYP, which revealed noticeable differences with previously published structures. The active...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747803/ https://ncbi.nlm.nih.gov/pubmed/19371084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900166y |
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