Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level

Vascular endothelial growth factor (VEGF) is a well-established stimulator of vascular permeability and angiogenesis, whereas thrombospondin-1 (TSP-1) is a potent angiogenic inhibitor. In this study, we have found that the TSP-1 receptors CD36 and β1 integrin associate with the VEGF receptor 2 (VEGF...

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Autori principali: Zhang, Xuefeng, Kazerounian, Shideh, Duquette, Mark, Perruzzi, Carole, Nagy, Janice A., Dvorak, Harold F., Parangi, Sareh, Lawler, Jack
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Federation of American Societies for Experimental Biology 2009
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747678/
https://ncbi.nlm.nih.gov/pubmed/19528255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-131649
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