Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase

CD36 plays a critical role in the inhibition of angiogenesis through binding to the type 1 repeats of thrombospondin-1 (TSP-1) and activating Fyn tyrosine kinase and MAPK pathways. Here, we reveal a novel association of CD36 with VEGFR-2 and spleen tyrosine kinase (Syk). We also address the correlat...

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Detalhes bibliográficos
Main Authors: Kazerounian, Shideh, Duquette, Mark, Reyes, Millys A., Lawler, James T., Song, Keli, Perruzzi, Carole, Primo, Luca, Khosravi-Far, Roya, Bussolino, Federico, Rabinovitz, Isaac, Lawler, Jack
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099580/
https://ncbi.nlm.nih.gov/pubmed/21378271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-305284
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