A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis

Deposits of Ig and complement are abundant in affected joints of patients with rheumatoid arthritis (RA) and in animal models of RA in which antibodies are demonstrably pathogenic. To identify molecular targets of the Igs deposited in arthritic joints, which may activate local inflammation, we used...

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Main Authors: Monach, Paul A., Hueber, Wolfgang, Kessler, Benedikt, Tomooka, Beren H., BenBarak, Maya, Simmons, Barry P., Wright, John, Thornhill, Thomas S., Monestier, Marc, Ploegh, Hidde, Robinson, William H., Mathis, Diane, Benoist, Christophe
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747210/
https://ncbi.nlm.nih.gov/pubmed/19720992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908032106
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