A continuous T-bet expression is required to silence the interleukin-4-producing potential in T helper type 1 cells

To develop into committed T helper type 1 (Th1) cells, naive CD4(+) T cells not only need to acquire the capacity to produce interferon-γ (IFN-γ), but they also need to gain the ability to silence their interleukin-4 (IL-4) -producing potential. How Th1 cells silence their Th2 cytokine-producing pot...

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Detalhes bibliográficos
Main Authors: Zhuang, Yonghua, Huang, Zan, Nishida, Jun, Brown, Melissa, Zhang, Lin, Huang, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747137/
https://ncbi.nlm.nih.gov/pubmed/19689734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2009.03049.x
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