pH Induced Conformational Change of Influenza M2 Protein C-terminal Domain

The M2 protein from influenza A is a pH-activated proton channel that plays an essential role in the viral life cycle and serves as a drug target. Using spin labeling EPR spectroscopy we studied a 38-residue M2 peptide spanning the transmembrane region and its C-terminal extension. We obtained resid...

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Bibliografiske detaljer
Main Authors: Nguyen, Phuong A., Soto, Cinque S., Polishchuk, Alexei, Caputo, Gregory A., Tatko, Chad D., Ma, Chunlong, Ohigashi, Yuki, Pinto, Lawrence H., DeGrado, William F., Howard, Kathleen P.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746938/
https://ncbi.nlm.nih.gov/pubmed/18754675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801315m
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