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Conformational rearrangements upon Syk auto-phosphorylation
Syk is a cytoplasmic tyrosine kinase that is activated after recruitment to immune receptors, triggering the phopshorylation of downstream targets. The kinase activity of Syk is controlled by an auto-inhibited conformation consisting of a regulatory region that contains two N-terminal Src homology 2...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746503/ https://ncbi.nlm.nih.gov/pubmed/19409513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2009.04.010 |
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