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Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3

Activation of Rho/Rac GTPases during cell signaling requires the participation of GDP/GTP exchange factors of the Dbl family. Although the structure of the catalytic core of Dbl proteins has been established recently, the molecular changes that the full-length proteins experience during normal or on...

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Main Authors: Llorca, Óscar, Arias-Palomo, Ernesto, Zugaza, José L, Bustelo, Xosé R
格式: Artigo
語言:Inglês
出版: 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142542/
https://ncbi.nlm.nih.gov/pubmed/15775967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600617
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