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Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1
Here we describe a new signaling cross-talk between the Vav/Rac1 and Ras pathways that is established through the stimulation of RasGRP1, an exchange factor for Ras subfamily GTPases. This interaction is crucial for Ras activation in lymphoid cells, since this GTPase cannot become activated in the a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC165641/ https://ncbi.nlm.nih.gov/pubmed/12839994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg316 |
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