Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

Here we describe a new signaling cross-talk between the Vav/Rac1 and Ras pathways that is established through the stimulation of RasGRP1, an exchange factor for Ras subfamily GTPases. This interaction is crucial for Ras activation in lymphoid cells, since this GTPase cannot become activated in the a...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Caloca, María J., Zugaza, José L., Matallanas, David, Crespo, Piero, Bustelo, Xosé R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165641/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12839994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg316
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