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Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

Here we describe a new signaling cross-talk between the Vav/Rac1 and Ras pathways that is established through the stimulation of RasGRP1, an exchange factor for Ras subfamily GTPases. This interaction is crucial for Ras activation in lymphoid cells, since this GTPase cannot become activated in the a...

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書誌詳細
主要な著者: Caloca, María J., Zugaza, José L., Matallanas, David, Crespo, Piero, Bustelo, Xosé R.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC165641/
https://ncbi.nlm.nih.gov/pubmed/12839994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg316
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