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Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling
The Syk protein-tyrosine kinase plays a major role in signaling through the B cell receptor for antigen (BCR). Syk binds the receptor via its tandem pair of SH2 domains interacting with a doubly phosphorylated immunoreceptor tyrosine-based activation motif (dp-ITAM) of the BCR complex. Upon phosphor...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2575281/ https://ncbi.nlm.nih.gov/pubmed/18689684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708583105 |
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