Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling

The Syk protein-tyrosine kinase plays a major role in signaling through the B cell receptor for antigen (BCR). Syk binds the receptor via its tandem pair of SH2 domains interacting with a doubly phosphorylated immunoreceptor tyrosine-based activation motif (dp-ITAM) of the BCR complex. Upon phosphor...

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Bibliografiske detaljer
Main Authors: Zhang, Yajie, Oh, Hyunju, Burton, Robert A., Burgner, John W., Geahlen, Robert L., Post, Carol Beth
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575281/
https://ncbi.nlm.nih.gov/pubmed/18689684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708583105
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