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Syk Inhibits the Activity of Protein Kinase A by Phosphorylating Tyrosine 330 of the Catalytic Subunit

The Syk protein-tyrosine kinase can have multiple effects on cancer cells, acting in some as a tumor suppressor by inhibiting motility and in others as a tumor promoter by enhancing survival. Phosphoproteomic analyses identified PKA as a Syk-specific substrate. Syk catalyzes the phosphorylation of t...

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Autores principales: Yu, Shuai, Huang, He, Iliuk, Anton, Wang, Wen-Horng, Jayasundera, Keerthi B., Tao, W. Andy, Post, Carol B., Geahlen, Robert L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624467/
https://ncbi.nlm.nih.gov/pubmed/23447535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426130
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