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Orotic Acid Decarboxylation in Water and Nonpolar Solvents: a Potential Role For Desolvation in the Action Of OMP Decarboxylase

OMP decarboxylase (ODCase) generates a very large rate enhancement without the assistance of metals or other cofactors. The uncatalyzed decarboxylation of 1-methylorotate in water is shown to involve the monoanion, although uncharged 1-methylorotic acid is decarboxylated at a similar rate. To measur...

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Detalles Bibliográficos
Main Authors: Lewis, Charles A., Wolfenden, Richard
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746487/
https://ncbi.nlm.nih.gov/pubmed/19678695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901085m
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