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Uroporphyrinogen decarboxylation as a benchmark for the catalytic proficiency of enzymes

The magnitude of an enzyme's affinity for the altered substrate in the transition state exceeds its affinity for the substrate in the ground state by a factor matching the rate enhancement that the enzyme produces. Particularly remarkable are those enzymes that act as simple protein catalysts,...

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Detalhes bibliográficos
Main Authors: Lewis, Charles A., Wolfenden, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582308/
https://ncbi.nlm.nih.gov/pubmed/18988736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809838105
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