Fractionated but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody

PURPOSE: This study tested the hypothesis that the type of dose-fractionation regimen determines the ability of radiotherapy to synergize with anti-CTLA-4 antibody. EXPERIMENTAL DESIGN: TSA mouse breast carcinoma cells were injected s.c. into syngeneic mice at two separate sites, defined as a “prima...

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Bibliographic Details
Main Authors: Dewan, M. Zahidunnabi, Galloway, Ashley E., Kawashima, Noriko, Dewyngaert, J. Keith, Babb, James S., Formenti, Silvia C., Demaria, Sandra
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746048/
https://ncbi.nlm.nih.gov/pubmed/19706802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0265
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