The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation

RET/PTC (RET/papillary thyroid carcinoma) oncoproteins result from the in-frame fusion of the RET receptor tyrosine kinase domain with protein dimerization motifs encoded by heterologous genes. Here we show that RET/PTC stimulates the β-catenin pathway. By stimulating PI3K/AKT and Ras/ERK, RET/PTC p...

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Main Authors: Castellone, Maria Domenica, De Falco, Valentina, Rao, Deva Magendra, Bellelli, Roberto, Muthu, Magesh, Basolo, Fulvio, Fusco, Alfredo, Gutkind, J. Silvio, Santoro, Massimo
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746012/
https://ncbi.nlm.nih.gov/pubmed/19223551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1982
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