siRNA nanoformulation against the Ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma

Delivery is a very important concern for therapeutic applications of siRNA. In this study, we have used chitosan-coated poly(isobutylcyanoacrylate) nanoparticles to deliver siRNA with a complementary sequence to the fusion oncogene ret/PTC1. By screening the mRNA junction we have selected a potent s...

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Bibliographische Detailangaben
Hauptverfasser: de Martimprey, Henri, Bertrand, Jean-Remi, Fusco, Alfredo, Santoro, Massimo, Couvreur, Patrick, Vauthier, Christine, Malvy, Claude
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248757/
https://ncbi.nlm.nih.gov/pubmed/18079153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1094
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