The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and activating mutations in the BRAF or RAS oncogenes are mutually exclusive. Here we show that the 3 proteins function along a linear oncogenic signaling cascade in which RET/PTC induces RAS-dependent BRAF activati...

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Autors principals: Melillo, Rosa Marina, Castellone, Maria Domenica, Guarino, Valentina, De Falco, Valentina, Cirafici, Anna Maria, Salvatore, Giuliana, Caiazzo, Fiorina, Basolo, Fulvio, Giannini, Riccardo, Kruhoffer, Mogens, Orntoft, Torben, Fusco, Alfredo, Santoro, Massimo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2005
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1062891/
https://ncbi.nlm.nih.gov/pubmed/15761501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522758
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