The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and activating mutations in the BRAF or RAS oncogenes are mutually exclusive. Here we show that the 3 proteins function along a linear oncogenic signaling cascade in which RET/PTC induces RAS-dependent BRAF activati...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Melillo, Rosa Marina, Castellone, Maria Domenica, Guarino, Valentina, De Falco, Valentina, Cirafici, Anna Maria, Salvatore, Giuliana, Caiazzo, Fiorina, Basolo, Fulvio, Giannini, Riccardo, Kruhoffer, Mogens, Orntoft, Torben, Fusco, Alfredo, Santoro, Massimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2005
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1062891/
https://ncbi.nlm.nih.gov/pubmed/15761501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522758
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi